Expression and Function of Bcl-2 Proteins in Melanoma
نویسندگان
چکیده
منابع مشابه
Expression and Function of Bcl-2 Proteins in Melanoma
Bcl-2 proteins are critical regulators of mitochondrial membrane permeability and the proapoptotic mitochondrial pathway. The family encloses pro- and antiapoptotic factors encoded by over 15 genes, which frequently give rise to alternative splice products. Antiapoptotic, proapoptotic multidomain, and proapoptotic BH3-only proteins are characterized by the presence of at least one of four Bcl-2...
متن کامل2253 BCL-2 expression in choroidal melanoma
Purpose: Lympboprolifcrativc ocular adnexal lesions represent 1 spectrum of disorders which range from reactive lymphoid hyperplasia to malignant lymphoma and include lewas which ared an mddcrminatc nature morphologrccally and immunophenotypically. Futhmnwe cases have been ckcvmented where progresswn from reactix hyperplasia to frank Ippboma has camed. We have applied molecular genetIc te&lques...
متن کاملBCL-2 proteins: melanoma lives on the edge
Melanoma is potentially a fatal skin malignancy with more than 80,000 new cases in the US annually resulting in nearly 10,000 deaths (www.cancer.gov). Mutations within the MAPK pathway are bona fide oncogenes that are mutated in ~80% of melanoma cases [1,2]. The MAPK pathway consists of a series of proteins that link a growth factor (e.g., EGF) activated plasma membrane receptor tyrosine kinase...
متن کاملimmunohistochemical expression of p53 and bcl-2 proteins in advanced esophageal cancer patients
the current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. we studied the p53 and bcl-2 protein expression in esophageal carcinomas to correlate molecular alterations with clinicopathological findings. tissue samples of 37 patients with advanced esophageal carcinoma were analyzed by imm...
متن کاملinterpersonal function of language in subtitling
translation as a comunicative process is always said to be associated with various aspects of meaning loss or gain. subtitling as a mode of translating, due to special discoursal and textual conditions imposed upon it, is believed to be an obvious case of this loss or gain. presenting the spoken sound track of a film in writing and synchronizing the perception of this text by the viewers with...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Genomics
سال: 2008
ISSN: 1389-2029
DOI: 10.2174/138920208785699571